Article
Herbicide exposure modifies GSTP1 haplotype association to Parkinson onset age: the GenePD Study.
Neurology - 26 Dec 2006
Wilk J B, Tobin J E, Suchowersky O, Shill H A, Klein C, Wooten G F, Lew M F, Mark M H, Guttman M, Watts R L, Singer C, Growdon J H, Latourelle J C, Saint-Hilaire M H, DeStefano A L, Prakash R, Williamson S, Berg C J, Sun M, Goldwurm S, Pezzoli G, Racette B A, Perlmutter J S, Parsian A, Baker K B, Giroux M L, Litvan I, Pramstaller P P, Nicholson G, Burn D J, Chinnery P F, Vieregge P, Slevin J T, Cambi F, MacDonald M E, Gusella J F, Myers R H, Golbe L I
Abstract excerpt
BACKGROUND: Polymorphisms in the glutathione S-transferase pi gene (GSTP1), encoding GSTP1-1, a detoxification enzyme, may increase the risk of Parkinson disease (PD) with exposure to pesticides. Using the GenePD Study sample of familial PD cases, we explored whether GSTP1 polymorphisms were asso...
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