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Genetic variation and pesticide exposure influence blood DNA methylation signatures in females with early-stage Parkinson’s disease

7 May 2024

Abstract excerpt

Abstract Although sex, genetics, and exposures can individually influence risk for sporadic Parkinson’s disease (PD), the joint contributions of these factors to the epigenetic etiology of PD have not been comprehensively assessed. Here, we profiled sex-stratified genome-wide blood DNAm patterns, SNP genotype, and pesticide exposure in agricultural workers (71 early-stage PD cases, 147 controls) and explored...

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PMID: 38714693
DOI: 10.1038/s41531-024-00704-3

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