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Article

Epidermal growth factor receptor activation: how exon 19 and 21 mutations changed our understanding of the pathway.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2006

Rosell Rafael, Taron Miquel, Reguart Noemi, Isla Dolores, Moran Teresa

Abstract excerpt

The discovery of epidermal growth factor receptor (EGFR) mutations in never-smokers has been the most relevant finding ever in non-small cell lung cancer. When patients whose tumors bear the sensitizing mutations are treated with the tyrosine kinase inhibitors gefitinib or erlotinib, we witness response rates and durations never before reported, including complete responses. At the same time, the presence of EGFR...

Topics

Antibodies, Monoclonal
Antibodies, Monoclonal, Humanized
Biomarkers, Tumor
Brain Neoplasms
Carcinoma, Non-Small-Cell Lung
Cetuximab
Clinical Trials as Topic
DNA Mutational Analysis
Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

ErbB Receptors

Gene Dosage

Glioma

Humans

Lung Neoplasms

Mutation

Patient Selection

Receptor, ErbB-2

Receptor, ErbB-3

Source

Identifiers

PMID: 17189393
DOI: 10.1158/1078-0432.CCR-06-0627

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17189393-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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