Impact of lineage-specific epidermal growth factor receptor mutations in cancer.

doi:10.1098/rstb.2024.0501

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Article

Impact of lineage-specific epidermal growth factor receptor mutations in cancer.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 27 Aug 2026

Rios Amy, Jorge Kimberly A, Ramirez Gizelle G, Thompson Chester A, Hayes Tikvah K

Abstract excerpt

The epidermal growth factor receptor, or EGFR, is one of the most frequently altered oncogenes in human cancer and is a critical therapeutic target. EGFR alterations span a broad spectrum, including gene amplification, point mutations, truncations, in-frame insertions or deletions, and fusions, yet their mutational distribution is cancer type-specific. This distribution impacts the effectiveness of EGFR-targeted...

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PMID: 42656145
DOI: 10.1098/rstb.2024.0501

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EGFR

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