Article
A functional single nucleotide polymorphism in the vitamin-K-dependent gamma-glutamyl carboxylase gene (Arg325Gln) is associated with bone mineral density in elderly Japanese women.
Bone - 1 Feb 2007
Kinoshita Hiroyuki, Nakagawa Kimie, Narusawa Ken'ichiro, Goseki-Sone Masae, Fukushi-Irie Mariko, Mizoi Lena, Yoshida Hideyo, Okano Toshio, Nakamura Toshitaka, Suzuki Takao, Inoue Satoshi, Orimo Hajime, Ouchi Yasuyoshi, Hosoi Takayuki
Abstract excerpt
The vitamin-K-dependent gamma-glutamyl carboxylase (GGCX) carboxylates vitamin-K-dependent proteins including bone Gla protein (osteocalcin) and matrix Gla protein, which play important roles in bone metabolism. Therefore, GGCX polymorphism might explain in part individual susceptibility to osteoporosis. In the present study, polymorphisms in the exons of this gene were screened in Japanese elderly women and a...
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