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Familial deficiency of vitamin K‐dependent clotting factors

30 Oct 2008

Abstract excerpt

Combined deficiency of vitamin K-dependent clotting factors II, VII, IX and X (and proteins C, S, and Z) is usually an acquired clinical problem, often resulting from liver disease, malabsorption, or warfarin overdose. A rare inherited form of defective gamma-carboxylation resulting in early onset of bleeding was first described by McMillan and Roberts in 1966 and subsequently has been termed 'vitamin K-dependent...

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PMID: 19141161
DOI: 10.1111/j.1365-2516.2008.01853.x

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