Article
Two French genotypes of hepatitis C virus: homology of the predominant genotype with the prototype American strain.
Gene - 15 Sept 1991
Li J S, Tong S P, Vitvitski L, Lepot D, Trépo C
Abstract excerpt
A hepatitis C virus (HCV) cDNA covering part of the nonstructural region, NS3, was amplified from the serum of 50 out of 76 French non-A, non-B hepatitis patients by the nested polymerase chain reaction (PCR). Determination of a 407-bp sequence from four such cases revealed the presence of two different virus genotypes, F1 and F2, which exhibited 19-20% sequence divergence. F1 was represented by three of the four...
Topics
- Americas
- Base Sequence
- Blotting, Southern
- DNA, Viral
- France
- Genotype
- Hepacivirus
- Hepatitis C
- Humans
- Japan
- Molecular Sequence Data
- Polymerase Chain Reaction