Article

A novel vascular endothelial growth factor-trap KP-VR2 with enhanced ligand blocking

2021-02-02

Abstract excerpt

Antiangiogenic therapies targeting vascular endothelial growth factor (VEGF)-A have been commonly used in clinics to treat cancers over the past decade. However, their clinical efficacy has been limited, with drawbacks including the acquisition of resistance and activation of compensatory pathways resulting from elevated circulating VEGF-B and placental growth factor (PlGF) levels. Thus, we developed a novel VEGF-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 22072500-54a0-5de7-ae88-eb0ab8faf140
DOI: 10.1101/2021.02.02.429416

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A novel vascular endothelial growth factor-trap KP-VR2 with enhanced ligand blockingDOI 10.1101/2021.02.02.429416Read

A mutated soluble neuropilin-2 B domain antagonizes vascular endothelial growth factor bioactivity and inhibits tumor progression.Semantic proximity Read

VEGF165b mutant with a prolonged half-life and enhanced anti-tumor potency in a mouse model.Semantic proximity Read

Molecular and functional diversity of vascular endothelial growth factors.Semantic proximity Read

Tivozanib, a highly potent and selective inhibitor of VEGF receptor tyrosine kinases, for the treatment of metastatic renal cell carcinoma.Semantic proximity Read

A novel variant of VEGFR2 identified by a pan-cancer screening of recurrent somatic mutations in the catalytic domain of tyrosine kinase receptors enhances tumor growth and metastasis.Semantic proximity Read

Anti-VEGF therapy: higher potency and long-lasting antagonism are not necessarily betterSemantic proximity Read

Current biology of VEGF-B and VEGF-CSemantic proximity Read

Resistance to Anti-Angiogenic Therapy in Cancer-Alterations to Anti-VEGF Pathway.Semantic proximity Read

A new perspective on antiangiogenic antibody drug resistance: Biomarkers, mechanisms, and strategies in malignanciesSemantic proximity Read

Structural determinants of growth factor binding and specificity by VEGF receptor 2.Semantic proximity Read

Novel VEGF family members: VEGF-B, VEGF-C and VEGF-DSemantic proximity Read

Loss of PTPRB function remodels VEGFR1 activation in tumors overexpressing the receptor tyrosine kinaseSemantic proximity Read