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Article

The genomic and epidemiological dynamics of human influenza A virus.

Nature - 29 May 2008

Rambaut Andrew, Pybus Oliver G, Nelson Martha I, Viboud Cecile, Taubenberger Jeffery K, Holmes Edward C

Abstract excerpt

The evolutionary interaction between influenza A virus and the human immune system, manifest as 'antigenic drift' of the viral haemagglutinin, is one of the best described patterns in molecular evolution. However, little is known about the genome-scale evolutionary dynamics of this pathogen. Similarly, how genomic processes relate to global influenza epidemiology, in which the A/H3N2 and A/H1N1 subtypes...

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Identifiers

PMID: 18418375
DOI: 10.1038/nature06945
PMCID: PMC2441973

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