Article
[The significance of IL-13 gene +2044G/A mutation in patients with inflammatory bowel disease].
Harefuah - 1 Nov 2006
Waterman Matti, Karban Amir, Nesher Shula, Weiss Batia, Shamir Raanan, Eliakim Rami
Abstract excerpt
BACKGROUND: Inflammatory bowel disease (IBD) is caused by a combination of genetic, immunological and environmental factors. Despite recent advances in the study of IBD pathogenesis, including the discovery of the NOD2/CARD15 mutation in 40% of Crohn's Disease (CD) patients, in most IBD patients no known mutations have yet been discovered. The interleukin (IL)-13 gene is located near the IBD5 locus on chromosome...
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