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Article

Critical role of DNA checkpoints in mediating genotoxic-stress-induced filamentous growth in Candida albicans.

Molecular biology of the cell - 1 Mar 2007

Shi Qing-Mei, Wang Yan-Ming, Zheng Xin-De, Lee Raymond Teck Ho, Wang Yue

Abstract excerpt

The polymorphic fungus Candida albicans switches from yeast to filamentous growth in response to a range of genotoxic insults, including inhibition of DNA synthesis by hydroxyurea (HU) or aphidicolin (AC), depletion of the ribonucleotide-reductase subunit Rnr2p, and DNA damage induced by methylmethane sulfonate (MMS) or UV light (UV). Deleting RAD53, which encodes a downstream effector kinase for both the...

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PMID: 17182857
DOI: 10.1091/mbc.e06-05-0442
PMCID: PMC1805102

Genes

MRC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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