Article
A fast and reliable single-run method for genotyping of the human cytochrome P450 2C8 gene for different ethnic groups.
Clinical laboratory - 1 Jan 2006
Weise A, Lambertz U, Thomé N, Bartz U, Krefft M, Mockenhaupt F, Bienzle U, Schöndorf T, Forst T, Pfützner A
Abstract excerpt
Patients vary widely in their response to drug therapy according to their genetic background of drug metabolizing enzymes. The cytochrome P450 enzyme CYP2C8 is one of the major metabolizing enzymes involved in drug metabolism and thus a candidate for routine pharmacogenetic screening. The aim of this work was establishing a fast and reliable method to detect the three CYP2C8 genotypes CYP2C8*2, CYP2C8*3,...
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