Article
Studying the right cell in acute myelogenous leukemia: dynamic changes of apoptosis and signal transduction pathway protein expression in chemotherapy resistant ex-vivo selected "survivor cells".
Cell cycle (Georgetown, Tex.) - 1 Dec 2006
Kornblau Steven M, Qiu Yi Hua, Bekele B N, Cade Jenny Straka, Zhou Xian, Harris David, Jackson C Ellen, Estrov Zeev, Andreeff Michael
Abstract excerpt
We hypothesized that studying protein expression in cells surviving in vitro chemotherapy ("survivor cells", SV), could provide more important insight into the biology of drug-resistant AML cells than analysis of the bulk population of leukemic cells. Leukemia-enriched samples from 79 patients with new or relapsed AML were cultured for four days +/- cytarabine (5-10 microM). Early apoptotic cells were removed to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.