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Article

Altered oncoprotein expression and apoptosis in myelodysplastic syndrome marrow cells

1 Dec 1996

Abstract excerpt

Ineffective hematopoiesis with associated cytopenias and potential evolution to acute myeloid leukemia (AML) characterize patients with myelodysplastic syndrome (MDS). We evaluated levels of apoptosis and of apoptosis-related oncoproteins (c-Myc, which enhances, and Bcl-2, which diminishes apoptosis) expressed within CD34+ and CD34- marrow cell populations of MDS patients (n = 24) to determine their potential...

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Identifiers

PMID: 8943864
DOI: 10.1182/blood.v88.11.4275.4275

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