Oncogenes are to lose control on signaling following mutation: should we aim off target?

Abstract excerpt

Rationalized cancer therapy aims at blocking overactive signaling pathways in cancer cells using kinase inhibitors. Essential for its success is the identification of suitable drug targets. Several recent reports have shown that by using control analysis, one can determine which component of a pathway is in control of its output. However, it has not been analyzed how a mutation in an oncogene affects the extent...

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