Article
Oncogenes come of age.
Cold Spring Harbor symposia on quantitative biology - 1 Jan 2005
Varmus H, Pao W, Politi K, Podsypanina K, Du Y-C N
Abstract excerpt
Mutations of proto-oncogenes are common events in the pathogenesis of cancers, as shown in a wide range of studies during the 30 years since the discovery of these genes. The benefits of novel therapies that target the products of mutant alleles in human cancers, and the demonstrated dependence of cancers in mouse models on continued expression of initiating oncogenes, are especially promising signs that...
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