Article
How are cancer associated genes activated or inactivated?
European journal of cancer (Oxford, England : 1990) - 1 Jan 1992
Wiedemann L M, Morgan G J
Abstract excerpt
Altered behaviour or the transformation of a cell can result from the abnormal expression of some oncogene products. Elevated or inappropriate expression can result from (i) mutations in the regulatory region of the gene, (ii) aberrant expression of a transcription factor involved in the regulation of the gene, (iii) gene amplification, or (iv) the insertion of a viral promoter upstream of the gene. In addition,...
Topics
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Humans
- Mutation
- Oncogenes
- Proto-Oncogene Mas
- Proto-Oncogenes
- Translocation, Genetic