Article
Three common alleles of KIR2DL4 (CD158d) encode constitutively expressed, inducible and secreted receptors in NK cells.
European journal of immunology - 1 Jan 2007
Goodridge Jodie P, Lathbury Louise J, Steiner Noriko K, Shulse Christine N, Pullikotil Philomena, Seidah Nabil G, Hurley Carolyn K, Christiansen Frank T, Witt Campbell S
Abstract excerpt
Genetic polymorphism of KIR2DL4 results in alleles with either 9 or 10 consecutive adenines in exon 6, which encodes the transmembrane domain. "10A" alleles encode a membrane-expressed receptor that is constitutively expressed on resting CD56bright NK cells and on CD56dim cells after culture. However, in some individuals with the 10A allele, KIR2DL4 cannot be detected on their resting CD56bright NK cells. "9A"...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.