Article
High-resolution structure of a retroviral protease folded as a monomer.
Acta crystallographica. Section D, Biological crystallography - 1 Nov 2011
Gilski Miroslaw, Kazmierczyk Maciej, Krzywda Szymon, Zábranská Helena, Cooper Seth, Popović Zoran, Khatib Firas, DiMaio Frank, Thompson James, Baker David, Pichová Iva, Jaskolski Mariusz
Abstract excerpt
Mason-Pfizer monkey virus (M-PMV), a D-type retrovirus assembling in the cytoplasm, causes simian acquired immunodeficiency syndrome (SAIDS) in rhesus monkeys. Its pepsin-like aspartic protease (retropepsin) is an integral part of the expressed retroviral polyproteins. As in all retroviral life cycles, release and dimerization of the protease (PR) is strictly required for polyprotein processing and virion...
Topics
- Animals
- Anti-Retroviral Agents
- Crystallization
- Crystallography, X-Ray
- Dimerization
- Disease Models, Animal
- Endopeptidases
- HIV Infections
- HIV-1
- Humans
- Macaca
- Mason-Pfizer monkey virus
- Molecular Targeted Therapy