Article
Structure-based secondary structure-independent approach to design protein ligands: Application to the design of Kv1.2 potassium channel blockers.
Journal of the American Chemical Society - 20 Dec 2006
Magis C, Gasparini D, Lecoq A, Le Du M H, Stura E, Charbonnier J B, Mourier G, Boulain J-C, Pardo L, Caruana A, Joly A, Lefranc M, Masella M, Menez A, Cuniasse P
Abstract excerpt
We have developed a structure-based approach to the design of protein ligands. This approach is based on the transfer of a functional binding motif of amino acids, often referred as to the "hot spot", on a host protein able to reproduce the functional topology of these residues. The scaffolds were identified by a systematic in silico search in the Protein Data Bank for proteins possessing a group of residues in a...
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