Article
Crystallization of protein-ligand complexes.
Acta crystallographica. Section D, Biological crystallography - 1 Jan 2007
Hassell Anne M, An Gang, Bledsoe Randy K, Bynum Jane M, Carter H Luke, Deng Su-Jun J, Gampe Robert T, Grisard Tamara E, Madauss Kevin P, Nolte Robert T, Rocque Warren J, Wang Liping, Weaver Kurt L, Williams Shawn P, Wisely G Bruce, Xu Robert, Shewchuk Lisa M
Abstract excerpt
Obtaining diffraction-quality crystals has long been a bottleneck in solving the three-dimensional structures of proteins. Often proteins may be stabilized when they are complexed with a substrate, nucleic acid, cofactor or small molecule. These ligands, on the other hand, have the potential to induce significant conformational changes to the protein and ab initio screening may be required to find a new crystal...
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