Article
A cholinergic receptor gene (CHRM2) affects event-related oscillations.
Behavior genetics - 1 Sept 2006
Jones Kevin A, Porjesz Bernice, Almasy Laura, Bierut Laura, Dick Danielle, Goate Alison, Hinrichs Anthony, Rice John P, Wang Jen C, Bauer Lance O, Crowe Raymond, Foroud Tatiana, Hesselbrock Victor, Kuperman Samuel, Nurnberger John, O'Connor Sean J, Rohrbaugh John, Schuckit Marc A, Tischfield Jay, Edenberg Howard J, Begleiter Henri
Abstract excerpt
We report genetic linkage and association findings which implicate the gene encoding the muscarinic acetylcholine receptor M2 (CHRM2) in the modulation of a scalp-recorded electrophysiological phenotype. The P3 (P300) response was evoked using a three-stimulus visual oddball paradigm and a phenotype that relates to the energy in the theta band (4-5 Hz) was analyzed. Studies have shown that similar...
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