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Article

Computational Design of a PDZ Domain Peptide Inhibitor that Rescues CFTR Activity

19 Apr 2012

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) is an epithelial chloride channel mutated in patients with cystic fibrosis (CF). The most prevalent CFTR mutation, ΔF508, blocks folding in the endoplasmic reticulum. Recent work has shown that some ΔF508-CFTR channel activity can be recovered by pharmaceutical modulators ("potentiators" and "correctors"), but ΔF508-CFTR can still be rapidly degraded...

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PMID: 22532795
DOI: 10.1371/journal.pcbi.1002477

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