Article
Presenilin mutations linked to familial Alzheimer's disease cause an imbalance in phosphatidylinositol 4,5-bisphosphate metabolism.
Proceedings of the National Academy of Sciences of the United States of America - 19 Dec 2006
Landman Natalie, Jeong Soon Youn, Shin Sun Young, Voronov Sergey V, Serban Geo, Kang Min Suk, Park Myung Kyu, Di Paolo Gilbert, Chung Sungkwon, Kim Tae-Wan
Abstract excerpt
Phosphatidylinositol 4,5-bisphosphate (PIP2) is an important cellular effector whose functions include the regulation of ion channels and membrane trafficking. Aberrant PIP2 metabolism has also been implicated in a variety of human disease states, e.g., cancer and diabetes. Here we report that familial Alzheimer's disease (FAD)-associated presenilin mutations cause an imbalance in PIP2 metabolism. We find that...
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