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CYP2D6 increases toxicity of the designer drug 4-methylthioamphetamine (4-MTA).

Toxicology - 18 Jan 2007

Carmo Helena, Brulport Marc, Hermes Matthias, Oesch Franz, de Boer Douwe, Remião Fernando, Carvalho Félix, Schön Michael R, Krebsfaenger Niels, Doehmer Johannes, Bastos Maria de Lourdes, Hengstler Jan G

Abstract excerpt

4-Methylthioamphetamine (4-MTA) belongs to a group of new amphetamine derivatives that is usually sold as "ecstasy" or "flatliners" on the illicit drug market. Large interindividual differences in 4-MTA mediated toxicity have been reported in humans. Therefore, we tested whether CYP2D6 or its variant alleles as well as CYP3A4 influence the susceptibility to 4-MTA. For this purpose, we used the colony formation...

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PMID: 17156908
DOI: 10.1016/j.tox.2006.10.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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