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Article

Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype.

European journal of clinical pharmacology - 1 May 2003

Berecz Roland, de la Rubia Alfredo, Dorado Pedro, Fernández-Salguero Pedro, Dahl Marja-Liisa, LLerena Adrián

Abstract excerpt

BACKGROUND: Approximately 7% of Caucasians have genetically impaired activity of the cytochrome P450 enzyme CYP2D6 and are classified as poor metabolizers (PM). The disposition of thioridazine has been related to the CYP2D6 phenotype. The present study aimed to evaluate the influence of CYP2D6 an...

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Source

Identifiers

PMID: 12682803
DOI: 10.1007/s00228-003-0576-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12682803-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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