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Article

Phosphoregulation of Arp2/3-dependent actin assembly during receptor-mediated endocytosis.

Nature cell biology - 1 Mar 2005

Toshima Jiro, Toshima Junko Y, Martin Adam C, Drubin David G

Abstract excerpt

In both yeast and mammals, endocytic internalization is accompanied by a transient burst of actin polymerization. The yeast protein kinases Prk1p and Ark1p, which are related to the mammalian proteins GAK and AAK1, are key regulators of this process. However, the molecular mechanism(s) by which they regulate actin assembly at endocytic sites have not yet been determined. The Eps15-like yeast protein Pan1p is a...

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Source

Identifiers

PMID: 15711538
DOI: 10.1038/ncb1229

Genes

AAK1
GAK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Phosphoregulation of Arp2/3-dependent actin assembly during receptor-mediated endocytosis.PMID 15711538Read ↗

A novel function of Arp2p in mediating Prk1p-specific regulation of actin and endocytosis in yeast.Semantic proximity Read ↗

Negative regulation of yeast Eps15-like Arp2/3 complex activator, Pan1p, by the Hip1R-related protein, Sla2p, during endocytosis.Semantic proximity Read ↗

Interaction of the endocytic scaffold protein Pan1 with the type I myosins contributes to the late stages of endocytosis.Semantic proximity Read ↗

Pan1p, yeast eps15, functions as a multivalent adaptor that coordinates protein-protein interactions essential for endocytosis.Semantic proximity Read ↗

Negative regulation of the actin-regulating kinase Prk1p by patch localization-induced autophosphorylation.Semantic proximity Read ↗

Scd5p mediates phosphoregulation of actin and endocytosis by the type 1 phosphatase Glc7p in yeast.Semantic proximity Read ↗

Role of Scd5, a protein phosphatase-1 targeting protein, in phosphoregulation of Sla1 during endocytosis.Semantic proximity Read ↗

Akr1p and the type I casein kinases act prior to the ubiquitination step of yeast endocytosis: Akr1p is required for kinase localization to the plasma membrane.Semantic proximity Read ↗

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Shared and specific functions of Arfs 1–5 at the Golgi revealed by systematic knockoutsSemantic proximity Read ↗

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