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Article

Preliminary investigations into triazole derived androgen receptor antagonists.

Bioorganic & medicinal chemistry - 1 May 2014

Altimari Jarrad M, Niranjan Birunthi, Risbridger Gail P, Schweiker Stephanie S, Lohning Anna E, Henderson Luke C

Abstract excerpt

A range of 1,4-substituted-1,2,3-N-phenyltriazoles were synthesized and evaluated as non-steroidal androgen receptor (AR) antagonists. The motivation for this study was to replace the N-phenyl amide portion of small molecule antiandrogens with a 1,2,3-triazole and determine effects, if any, on biological activity. The synthetic methodology presented herein is robust, high yielding and extremely rapid. Using this...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24726305
DOI: 10.1016/j.bmc.2014.03.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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