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Article

Role of the second transmembrane domain of rat adenosine A1 receptor in ligand-receptor interaction.

Biochemical pharmacology - 14 Mar 2006

Xie Ke-Qiang, Cao Yan, Zhu Xing-Zu

Abstract excerpt

Initial mutagenesis studies exploring the ligand recognition model of A1 adenosine receptor (A1R) mainly focused on the residues in the 5th-7th transmembrane domains (TMs5-7). Little is known about the role of residues in TM2. To explore the importance of reserved hydrophobic region in TM2 of A1R, we mutated the hydrophobic residues at positions 65 and 69 to hydrophilic residues (L65T, Leu-65 to Thr-65; I69T,...

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Source

Identifiers

PMID: 16414025
DOI: 10.1016/j.bcp.2005.12.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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