Article
Direct correlation between double K-RAS mutation and mucinous carcinoma. A case report.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Feb 2015
Pacini Luca, Bastianelli Daniela, Ponti Donatella, Rosa Paolo, Petrozza Vincenzo, Giannini Giuseppe, Ragona Giuseppe, Calogero Antonella
Abstract excerpt
Mutations at the K-RAS locus in colon cancer cells are frequently associated with lack of responsiveness to therapy with EGFR inhibitors, as a consequence of the activation of Ras-dependent intracellular signals. Here we report a colon cancer case carrying a novel combination of K-RAS mutations involving codon 13 (Gly to Asp) and codon 19 (Leu to Phe), on separate alleles. The double mutation was restricted to...
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