Article
A Comparison of Gene Expression Signatures from Breast Tumors and Breast Tissue Derived Cell Lines
1 Jan 2001
Abstract excerpt
Cell lines derived from human tumors have historically served as the primary experimental model system for exploration of tumor cell biology and pharmacology. Cell line studies, however, must be interpreted in the context of artifacts introduced by selection and establishment of cell lines in vitro. This complication has led to difficulty in the extrapolation of biology observed in cell lines to tumor biology in...
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