Article
Mutation screen of the cone-specific gene, CLUL1, in 376 patients with age-related macular degeneration.
Ophthalmic genetics - 1 Dec 2006
Sturgill Gwen M, Pauer Gayle J T, Bala Elisa, Simpson Ellen, Yaniglos Stacia S, Crabb John W, Hollyfield Joe G, Lewis Hilel, Peachey Neal S, Hagstrom Stephanie A
Abstract excerpt
Clusterin is a secreted glycoprotein expressed ubiquitously in many tissues that appears to function as a molecular chaperone capable of protecting stressed proteins. It is upregulated in many different forms of neurodegeneration and is thought to represent a defense response against neuronal damage. Clusterin has been found to be a common protein identified in drusen preparations isolated from the retina of...
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