Article
Evaluation of the ARMD1 locus on 1q25-31 in patients with age-related maculopathy: genetic variation in laminin genes and in exon 104 of HEMICENTIN-1.
Ophthalmic genetics - 1 Jun 2004
Hayashi M, Merriam J E, Klaver C C W, Zernant J, Bergen A A, Smith R T, Chang S, Merriam J C, Allikmets R
Abstract excerpt
The age-related maculopathy (ARM) genetics program at Columbia University utilizes comprehensive genetic analysis of candidate genes in large case-control studies to determine genotypes associated with the ARM complex trait. Genes encoding laminins, a class of extracellular matrix proteins, represent attractive candidates for two reasons. First, the presence of laminins in the basal lamina of the retinal pigment...
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