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Article

Curative Stem Cell Transplantation for Severe Hb H Disease Manifesting From Early Infancy: Phenotypic and Genotypic Analyses.

Hemoglobin - 1 Jan 2016

Surapolchai Pacharapan, Sirachainan Nongnuch, So Chi-Chiu, Hongeng Suradej, Pakakasama Samart, Anurathapan Usanarat, Chuansumrit Ampaiwan

Abstract excerpt

Most people with Hb H disease live normal lives; however, a minority of cases requires lifelong regular transfusions. An atypical form of nondeletional Hb H disease was reported in a Thai boy, characterized by severe persistent hemolytic anemia since the age of 2 months. Molecular diagnosis revealed the apparent compound heterozygosity for the Southeast Asian (- -(SEA)) and α2 polyadenylation (polyA) signal...

Topics

Genotype
Hemoglobin H
Heterozygote
Humans
Infant
Male
Polyadenylation
Sequence Deletion
Stem Cell Transplantation
Transplantation, Homologous
alpha-Thalassemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26575104
DOI: 10.3109/03630269.2015.1105815

Genes

SEA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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