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Article

A novel strategy for defining haplotypes by selective depletion using restriction enzymes.

Immunogenetics - 1 Jan 2007

Smirnova Anna S, Ferreira-Silva Kátia C, Mine Karina L, Andrade-Oliveira Vinicius, Shulzhenko Natalia, Gerbase-DeLima Maria, Morgun Andrey

Abstract excerpt

Various single nucleotide polymorphisms (SNPs) have been investigated regarding association with gene expression levels or human diseases. Although different SNPs within one gene are frequently analyzed individually, it is highly probable that in the majority of the cases, a precise combination of SNP alleles, i.e., haplotype, determines a functional trait. Methods commonly used for haplotype determination,...

Topics

Alleles
Brazil
DNA Restriction Enzymes
Genetic Testing
Genotype
Haplotypes
Humans
Lymphotoxin-alpha
Polymerase Chain Reaction
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17146685
DOI: 10.1007/s00251-006-0172-8

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LTA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17146685-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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