Article
Hypervirulence of a rough variant of the Mycobacterium abscessus type strain.
Infection and immunity - 1 Feb 2007
Catherinot E, Clarissou J, Etienne G, Ripoll F, Emile J-F, Daffé M, Perronne C, Soudais C, Gaillard J-L, Rottman M
Abstract excerpt
We isolated a rough variant of Mycobacterium abscessus CIP 104536T during experimental infection of mice. We show that this variant has lost the ability to produce glycopeptidolipids, is hyperlethal for C57BL/6 mice infected intravenously, and induces a strong tumor necrosis factor-alpha response by murine monocyte-derived macrophages.
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