Article
Mutational analysis of the BRAF gene in colorectal mucinous carcinoma in association with histological configuration.
Oncology reports - 1 Jan 2007
Yoshitake Naoto, Fujii Shigehiko, Mukawa Kenichiroh, Tominaga Keiichi, Fukui Hirokazu, Ichikawa Kazuhito, Tomita Shigeki, Ono Yuko, Imai Yasuo, Terano Akira, Hiraishi Hideyuki, Fujimori Takahiro
Abstract excerpt
Genetic alterations and their association with clinicopathological features in colorectal mucinous carcinoma (MC) remain unknown. In particular, little is known about the mutational status of the BRAF gene, which is activated by oncogenic Ras. This study aimed to evaluate the status of BRAF toget...
Topics
- Adaptor Proteins, Signal Transducing
- Adenocarcinoma, Mucinous
- Adult
- Aged
- Aged, 80 and over
- Carrier Proteins
- Colorectal Neoplasms
- DNA Mismatch Repair
- DNA Mutational Analysis
- Female
- Genes, p53
- Genes, ras
- Humans
- Immunohistochemistry