Article
Functional studies of aldo-keto reductases in Saccharomyces cerevisiae.
Biochimica et biophysica acta - 1 Mar 2007
Chang Qing, Griest Terry A, Harter Theresa M, Petrash J Mark
Abstract excerpt
We utilized the budding yeast Saccharomyces cerevisiae as a model to systematically explore physiological roles for yeast and mammalian aldo-keto reductases. Six open reading frames encoding putative aldo-keto reductases were identified when the yeast genome was queried against the sequence for human aldose reductase, the prototypical mammalian aldo-keto reductase. Recombinant proteins produced from five of these...
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