Article
Functional genomic studies of aldo-keto reductases.
Chemico-biological interactions - 30 Jan 2001
Petrash J M, Murthy B S, Young M, Morris K, Rikimaru L, Griest T A, Harter T
Abstract excerpt
Aldose reductase (AR) is considered a potential mediator of diabetic complications and is a drug target for inhibitors of diabetic retinopathy and neuropathy in clinical trials. However, the physiological role of this enzyme still has not been established. Since effective inhibition of diabetic complications will require early intervention, it is important to delineate whether AR fulfills a physiological role...
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