Article
Polymorphisms of the vitamin D receptor gene predict the onset of surgical menopause in Caucasian females.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology - 1 Oct 2006
Dvornyk Volodymyr, Long Ji-Rong, Liu Peng-Yuan, Shen Hui, Recker Robert R, Deng Hong-Wen
Abstract excerpt
We tested association of four single nucleotide polymorphisms (SNPs) of the vitamin D receptor gene (VDR) with age at surgical and natural menopause in a sample of Caucasians composed of 153 women with surgical and 260 with natural menopause. A significant association was observed between age at surgical menopause and two SNPs, rs1544410 (BsmI) and rs731236 (TaqI) (p < 0.05). For rs1544410, homozygotes of the...
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