Article
The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians.
Diabetes - 1 Sept 2000
Rasmussen S K, Urhammer S A, Pizzuti A, Echwald S M, Ekstrøm C T, Hansen L, Hansen T, Borch-Johnsen K, Frittitta L, Trischitta V, Pedersen O
Abstract excerpt
The human plasma-cell membrane differentiation antigen-1 (PC-1) has been shown to inhibit insulin receptor tyrosine kinase activity. Recently, a K121Q polymorphism in the human PC-1 gene was found in a Sicilian population and was shown to be strongly associated with insulin resistance. The objectives of the present investigation were to examine in the Danish Caucasian population whether the K121Q variant was...
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