Article
Cytochrome P450 expression (CYP) in non-small cell lung cancer.
Frontiers in bioscience : a journal and virtual library - 1 Jan 2007
Oyama Tsunehiro, Sugio Kenji, Uramoto Hidetaka, Kawamoto Toshihiro, Kagawa Norio, Nadaf Sorena, Carbone David, Yasumoto Kosei
Abstract excerpt
The cytochrome P450 (CYP) is associated with tumor development and progression as well as activation of anti-cancer prodrugs and their metabolic clearance. In this study, we investigated the expression of aryl-hydrocarbon receptor (AH-R) and four CYPs (CYP1A1, CYP2A6, CYP2E1 and CYP3A) as putative diagnostic markers in 78 non-small cell lung cancers (NSCLC) along with clinical features of the patients. In...
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