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Article

Association study of tryptophan hydroxylase 2 gene polymorphisms in panic disorder.

Neuroscience letters - 16 Jan 2007

Maron Eduard, Tõru Innar, Must Anne, Tasa Gunnar, Toover Egle, Vasar Veiko, Lang Aavo, Shlik Jakov

Abstract excerpt

Experimental studies on serotonin (5-HT) availability suggest a role for 5-HT synthesis rate in panicogenesis. Recently, it has been discovered that the tryptophan hydroxylase gene isoform 2 (TPH2), rather than TPH1, is preferentially expressed in the neuronal tissue and, therefore, is primarily responsible for the regulation of brain 5-HT synthesis. In the present case-control genetic association study we...

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Source

Identifiers

PMID: 17123728
DOI: 10.1016/j.neulet.2006.09.060

Genes

TPH2
TPH1

Provenance

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