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Article

Mitochondrial-nuclear cross-talk in the aging and failing heart.

Cardiovascular drugs and therapy - 1 Dec 2006

Marín-García José, Pi YeQing, Goldenthal Michael J

Abstract excerpt

HYPOTHESIS: Damage to heart mitochondrial structure and function occur with aging, and in heart failure (HF). However, the extent of mitochondrial dysfunction, the expression of mitochondrial and nuclear genes, and their cross-talk is not known. OBSERVATIONS: Several observations have suggested that somatic mutations in mitochondrial DNA (mtDNA), induced by reactive oxygen species (ROS), appear to be the primary...

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Identifiers

PMID: 17119872
DOI: 10.1007/s10557-006-0584-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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