Article
[The role of regulatory T-cells in autoimmune rheumatic diseases].
Vestnik Rossiiskoi akademii meditsinskikh nauk - 1 Jan 2006
Nasonov E L, Bykovskaia S N
Abstract excerpt
Regulatory T-cells CD4+CD25+Foxp3, possessing suppressory activity, play the key role in the development of autoimmune diseases, maintenance of peripheral tolerance in transplantation immunity, and the prevention of a pathological immune response to intestinal microflora or microbial infection. A decrease in the total number of circulating CD4+CD25+ regulatory T-cells and their suppressive activity have been...
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