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Article

[The role of regulatory T-cells in autoimmune rheumatic diseases].

Vestnik Rossiiskoi akademii meditsinskikh nauk - 1 Jan 2006

Nasonov E L, Bykovskaia S N

Abstract excerpt

Regulatory T-cells CD4+CD25+Foxp3, possessing suppressory activity, play the key role in the development of autoimmune diseases, maintenance of peripheral tolerance in transplantation immunity, and the prevention of a pathological immune response to intestinal microflora or microbial infection. A decrease in the total number of circulating CD4+CD25+ regulatory T-cells and their suppressive activity have been...

Topics

Animals
Anti-Inflammatory Agents
Antibodies, Antinuclear
Antirheumatic Agents
Arthritis, Rheumatoid
Autoimmune Diseases
Cells, Cultured
Cyclophosphamide
Disease Models, Animal
Female
Glucocorticoids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunosuppressive Agents

Lupus Erythematosus, Systemic

Lymphocyte Activation

Male

Methylprednisolone

Mice

Source

Identifiers

PMID: 17111929

Provenance

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