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Article

Respiratory impairment in a mouse model of amyotrophic lateral sclerosis.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Mar 2007

Tankersley Clarke G, Haenggeli Christine, Rothstein Jeffery D

Abstract excerpt

Amyothrophic lateral sclerosis (ALS) is a progressive, lethal neuromuscular disease that is associated with the degeneration of cortical and spinal motoneurons, leading to atrophy of limb, axial, and respiratory muscles. Patients with ALS invariably develop respiratory muscle weakness and most die from pulmonary complications. Overexpression of superoxide dismutase 1 (SOD1) gene mutations in mice recapitulates...

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Identifiers

PMID: 17110520
DOI: 10.1152/japplphysiol.00193.2006

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SOD1

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