Article
Neural basis for mutant ATAXIN-1 induced respiratory dysfunction in mouse models of spinocerebellar ataxia type 1.
Neurobiology of disease - 1 May 2026
Soles Alyssa, Grittner Jessica, Douglas Kaia, Yang Praseuth, Duvick Lisa, O'Callaghan Brennon, Barnett Ryan, Chau Christine, Cosiquien Roj, Rainwater Orion, Serres Shannah, Dougherty Brendan, Orr Harry T, Cvetanovic Marija
Abstract excerpt
Spinocerebellar ataxia type 1 is a neurodegenerative disease characterized by motor dysfunction and premature death usually from compromised swallowing and respiration. Using plethysmography, we characterized respiration in the conditional f-ATXN1146Q/2Q SCA1 model. We found a progressive elevation of baseline respiration that impairs ability of f-ATXN1146Q/2Q mice to increase breathing during challenge. To...
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