Article
Detection of epidermal growth factor receptor variations by partially denaturing HPLC.
Clinical chemistry - 1 Jan 2007
Chin Tan Min, Anuar Diyanah, Soo Ross, Salto-Tellez Manuel, Li Wei Qi, Ahmad Baidah, Lee Soo Chin, Goh Boon Cher, Kawakami Kazuyuki, Segal Amanda, Iacopetta Barry, Soong Richie
Abstract excerpt
BACKGROUND: Epidermal growth factor receptor gene (EGFR) variants may be useful markers for identifying responders to gefitinib and erlotinib, small-molecule tyrosine kinase inhibitors of EGFR; therefore, sensitive and cost-effective assays are needed to detect EGFR variants in routine clinical s...
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