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Article

Assessment of the Influence of Inflammation and FCGR3A Genotype on Infliximab Pharmacokinetics and Time to Relapse in Patients with Crohn's Disease.

Clinical pharmacokinetics - 1 May 2015

Ternant David, Berkane Zahir, Picon Laurence, Gouilleux-Gruart Valérie, Colombel Jean-Frédéric, Allez Matthieu, Louis Edouard, Paintaud Gilles

Abstract excerpt

BACKGROUND AND OBJECTIVES: Infliximab is a monoclonal anti-tumor necrosis factor-α (anti-TNFα) antibody that profoundly modified the treatment of Crohn's disease (CD). The polymorphism of Fc fragment of IgG, low affinity IIIa, receptor (CD16a) [FCGR3A] influences the biological response to infliximab in patients with CD. Our aim was to study its influence on infliximab pharmacokinetics and risk of relapse after...

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Identifiers

PMID: 25516415
DOI: 10.1007/s40262-014-0225-3

Genes

CRP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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