Article
The extracellular linker of pro-neuregulin-alpha2c is required for efficient sorting and juxtacrine function.
Molecular biology of the cell - 1 Feb 2007
Montero Juan C, Rodríguez-Barrueco Ruth, Yuste Laura, Juanes Pedro P, Borges Joana, Esparís-Ogando Azucena, Pandiella Atanasio
Abstract excerpt
The neuregulins (NRGs) play important roles in animal physiology, and their disregulation has been linked to diseases such as cancer or schizophrenia. The NRGs may be produced as transmembrane proteins (proNRGs), even though they lack an N-terminal signal sequence. This raises the question of how NRGs are sorted to the plasma membrane. It is also unclear whether in their transmembrane state, the NRGs are...
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